Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. *Okada K, Ito D, Morimoto S, Kato C, Oguma Y, Warita H, Suzuki N, Aoki M, Kuramoto J, Kobayashi R, Shinozaki M, Ikawa M, Nakahara J, Takahashi S, Nishimoto Y, Shibata S and Okano H*.
  "Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS-ALS."
  Brain, 147(11):3933-3948, 2024.
• 2. *Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H*.
  "Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H*. Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery."
  Cell Stem Cell. 30(6):766-780, 2023.
• 3. *Okano H* and Morimoto S.
  "iPSC-based disease modeling and drug-discovery in cardinal neurodegenerative disorders."
  Cell Stem Cell, 29, 189-208, 2022.
• 4. Shimada H, Sato Y, Sasaki T, Shimozawa A, Imaizumi K, Shindo T, Miyao S, Kiyama K, Kondo T, Shibata S, Ishii S, Kuromitsu J, Aoyagi H, Ito D, Okano H*.
  "A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer.
  Cell Reports Methods, 2(9):100289, 2022
• 5. *Heide M, Haffner C, Murayama A, Kurotaki Y, Shinohara H, Okano H, Sasaki E and Huttner WB.
  "Human-specific ARHGAP11B increases size and folding of the fetal neocortex of a non-human primate."
  Science 369(6503):546-550, 2020.
• 6. *Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H*
  "Modeling sporadic ALS and identification of a potential therapeutic agent in iPSC-derived motor neurons."
  Nature Medicine 24(10):1579-1589, 2018.
• 7. Okano H*, Sasaki E, Yamamori T, Iriki A, Shimogori T, Yamaguchi Y, Kasai K and Miyawaki A.
  "Brain/MINDS: a Japanese National Brain Project for Marmoset Neuroscience."
  Neuron 92 (3): 582-590, 2016.
• 8. *Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, Nakagawa M, Koyanagi M, Tanabe K, Ohnuki M, Ogawa D, Ikeda E, Okano H*, Yamanaka S.
  "Variation in the safety of induced pluripotent stem cell lines."
  Nature Biotechnol. 27(8): 743-745, 2009
• 9. Sasaki E*, Suemizu H, Shimada A, Hanazawa K, Oiwa R, Kamioka M, Sotomaru Y, Hirakawa R, Eto T, Shiozawa S, Maeda T, Ito R, Kito C, Yagihashi C, Kawai K, Miyoshi H, Tanioka Y, Tamaoki N, Habu S, Okano H**, Nomura T
  "Generation of transgenic non-human primates with germ line transmission."
  Nature, 459(7246): 523-527, 2009.
• 10. Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H*
  "Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury."
  Nature Medicine12(7): 829-834, 2006

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