RIKEN Center for Sustainable Resource Science Catalysis and Integrated Research Group

Group Director: Mikiko Sodeoka (D.Phar.)

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Research Summary

Our group focuses on the development of novel transition metal-catalyzed reactions and exploitation of functions of the reaction products, and on conducting integrated research of plant science and chemistry with emphasis on sustainable resource science. Specifically, we develop new organic synthetic methodologies utilizing ubiquitous metals, such as copper and iron, as catalysts to achieve the efficient conversion of carbon resources into valuable materials. Additionally, we explore the effective utilization of secondary metabolites of plants. In particular, we are studying various aspects of secondary metabolites of plants, whose effects on plants and animals have not been well clarified. Furthermore, this group will also contribute to enhance the collaboration between plant/microbiology research and chemical research activities inside CSRS.

Main Research Fields

Chemistry

Related Research Fields

Biological Sciences
Medicine, Dentistry & Pharmacy

Keywords

Bioactive Molecule
Catalytic Reaction
Fluorine-Containing Molecules

Selected Publications

1.Mukherjee, S., Kawamura, S., and Sodeoka, M.:
"LMCT Photocatalysis Coupled with Halogen-atom Transfer (XAT) for Difunctionalizing Alkene Fluoroalkylation"
Adv. Synth. Cat. 368, e70265 (2026).
2.Mukherjee, S., Kubota, A., Kawamura, S., and Sodeoka, M.:
"Iron-photocatalyzed Anti-Markovnikov Hydrochlorination of Alkenes Based on Ligand-to-metal Charge Transfer"
ChemistryEurope 3, e202500258 (2025).
3.Dodo, K., Tipping, W. J., Yamakoshi, H., Egoshi, S., Kubo, T., Kumamoto, Y., Faulds, K., Graham, D., Fujita, K., and Sodeoka, M.:
"Alkyne-tag Raman Imaging and Sensing of Bioactive Compounds"
Nat. Rev. Methods Prim., 5, 20 (2025).
4.Mizushima, K., Kumamoto, Y., Tamura, S., Yamanaka, M., Mochizuki, K., Li, M., Egoshi, S., Dodo, K., Harada, Y., Smith, N. I., Sodeoka, M., Tanaka, H., and Fujita, K.:
"Raman Microscopy of Cryofixed Biological Specimens for High-Resolution and High-Signal-to-Noise-Ratio Chemical Imaging"
Sci. Adv. 10, eadn0110 (2024).
5.Mukherjee, S., Kawamura, S., and Sodeoka, M.:
"Ligand-Controlled Copper-Catalyzed Halo-Halodifluoromethylation of Alkenes and Alkynes Using Fluorinated Carboxylic Anhydrides"
Angew. Chem., Int. Ed., 63, e202407150 (2024).
6.Pünner, F., Sohtome, Y., Lyu, Y., Hashizume, D., Akakabe, M., Yoshimura, M., Yashiroda, Y., Yoshida, M., and Sodeoka, M.:
"Catalytic Aerobic Carbooxygenation for the Construction of Vicinal Tetrasubstituted Centers: Application to the Synthesis of Hexasubstituted γ-Lactones"
Angew. Chem., Int. Ed., 63, e202405876 (2024).
7.Hayamizu, K., Koike, K., Dodo, K., Asanuma, M., Egami, H., Sodeoka, M.:
"Simple Purification of Small-Molecule-Labelled Peptides via Palladium Enolate Formation from β-Ketoamide Tags"
Chem. Sci., 14, 8249-8254 (2023).
8.Kawamura, S., Sodeoka, M.:
"Understanding and Controlling Fluorinated Diacyl Peroxides and Fluoroalkyl Radicals in Alkene Fluoroalkylations"
Chem. Rec., 23, e202300202 (2023).
9.Toh, K., Nishio, K., Nakagawa, R., Egoshi, S., Abo, M., Perron, A., Sato, S.-i., Okumura, N., Koizumi, N., Dodo, K., Sodeoka, M., Uesugi, M.:
"Chemoproteomic Identification of Blue-Light-Damaged Proteins"
J. Am. Chem. Soc., 144, 20171-20176 (2022).
10.Dodo, K., Fujita, K., Sodeoka, M.:
"Raman Spectroscopy for Chemical Biology Research"
J. Am. Chem. Soc., 144, 19651-19667 (2022).