Research Summary

Selected Publications

• 1. Jiang, X., Ichinose, S., Ogawa, T., Yonezawa, K., Shimizu, N., and Hirokawa, N.:
  "The KIF3B/B/KAP3 tail domain specifically facilitates TRIM46 transport to the axon initial segment”
  Journal of Cell Biology 225(5), e202503138 (2026).
• 2. Ishihara, K., Matsumoto, S., Gerle, C., Gopalasingam, C. C., Shigematsu, H., Shirai, T., and Numata, T.:
  "Sequential structural rearrangements at the PAM-distal site of a type I-F3 CRISPR-Cas effector enabling RNA-guided DNA transposition”
  Nucleic Acids Research 54(1), gkaf1415 (2026).
• 3. Ishida, S., Sato, Y., Chosa, K., Ezawa, E., Yamauchi, Y., Oyama, M., Kozuka-Hata, H., Ito, R., Sato, R., Maeki, M., Ishikawa, T., Yamamura, K., Takeshita, K., Yamaguchi, K., Kochi, Y., Hashiya, F., Liu, Y., Abe, N., Abe, H., Sekijima, Y., Yoshimi, K., and Mashimo, T.:
  "CRISPR-Cas3-based editing for targeted deletions in a mouse model of transthyretin amyloidosis”
  Nature Biotechnology (2026).
• 4. Nakano, A., Kishikawa, J., Yui, N., Sugawara, K., Kan, Y., Gerle, C., Shigematsu, H., Mitsuoka, K., and Yokoyama, K.:
  "Structures of rotary ATP synthase from Thermus thermophilus during proton powered ATP synthesis”
  Science Advances 11(42), eadx8771 (2025).
• 5. Furukawa, A., Yonezawa, K., Negami, T., Yoshimura, Y., Hayashi, A., Nakayama, J., Adachi, N., Senda, T., Shimizu, K., Terada, T., Shimizu, N., and Nishimura, Y.:
  "A dynamic structural unit of phase-separated heterochromatin protein 1α as revealed by integrative structural analyses”
  Nucleic Acids Research 53(6), gkaf154 (2025).
• 6. Shimizu, N., Luo, F., Tanaka, T., Tono, K., Yatabe, K., Iwata, S., and Nango, E.:
  "Time-resolved small-angle X-ray scattering system development for the biological macromolecules at SACLA: A pilot study”
  Biophysics and Physicobiology 22(2), e220007 (2025).
• 7. Yoshimi, K., Takeshita, K., Kodera, N., Shibumura, S., Yamauchi, Y., Omatsu, M., Umeda, K., Kunihiro, Y., Yamamoto, M., and Mashimo, T.:
  "Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas3"
  Nature Communications 13(1), 4917 (2022).
• 8. Gopalasingam, C.C., and Hasnain, S.S.:
  "Frontiers in metalloprotein crystallography and cryogenic electron microscopy"
  Current Opinion in Structural Biology 75, 102420 (2022).
• 9. Baba, S., Matsuura, H., Kawamura, T., Sakai, N., Nakamura, Y., Kawano, Y., Mizuno, N., Kumasaka, T., Yamamoto, M., and Hirata, K.:
  "Guidelines for de novo phasing using multiple small-wedge data collection"
  Journal of Synchrotron Radiation 28(5), 1284-1295 (2021).
• 10. Yamamoto, M., Hirata, K., Yamashita, K., Hasegawa, K., Ueno, G., Ago, H., and Kumasaka, T.:
  "Protein microcrystallography using synchrotron radiation"
  IUCrJ 4(5), 529-539 (2017).

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