Research Summary

Selected Publications

• 1. Shinoda, T., Katsura, K., Ishizuka-Katsura, Y., Hanada, K., Yonemochi, M., Miyamoto, Y., Kukimoto-Niino, M., Yamauchi, J., and Shirouzu, M.:
  "Conformational alteration of DOCK5•ELMO1 signalosome on lipid membrane"
  Commun Biol. 8(1), 1523. (2025).
• 2. Fujiwara, T., Hosaka, T., Hasegawa-Takano, M., Nishimura, Y., Tominaga, K., Mori, K., Nishino, S., Takahashi, Y., Uchikubo-Kamo, T., Hanada, K., Maoka, T., Takaichi, S., Inoue, K., Shirouzu, M., and Yoshizawa, S.:
  "Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota"
  Nature Microbiology 10(10), 2603–2615. (2025).
• 3. Kaneko, S., Imai, S., Kamo, T., Hisano, T., Asao, N., Shirouzu, M., and Shimada, I.:
  "Structural and dynamic insights into the activation of the μ-opioid receptor by an allosteric modulator"
  Nat. Commun. 15(1), 3544. (2024).
• 4. Yamagata, A., Ito, K., Suzuki, T., Dohmae, N., Terada, T., and Shirouzu, M.:
  "Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A"
  Nat. Commun. 15(1), 3027. (2024).
• 5. Zhao, X., Ma, D., Ishiguro, K., Saito, H., Akichika, S., Matsuzawa, I., Mito, M., Irie, T., Ishibashi, K., Wakabayashi, K., Sakaguchi, Y., Yokoyama, T., Mishima, Y., Shirouzu, M., Iwasaki, S., Suzuki, T., and Suzuki, T.:
  "Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth"
  Cell 186(25), 5517–5535.e24. (2023).
• 6. Yamagata, A., Murata, Y., Namba, K., Terada, T., Fukai, S., and Shirouzu, M.:
  "Uptake mechanism of iron-phytosiderophore from the soil based on the structure of yellow stripe transporter"
  Nat. Commun. 13(1), 7180. (2022).
• 7. Ehara, H., Kujirai, T., Shirouzu, M., Kurumizaka, H., and Sekine, S.:
  "Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT"
  Science 377(6611), eabp9466. (2022).
• 8. Park, J., Iwamoto, M., Yun, J., Uchikubo-Kamo, T., Son, D., Jin, Z., Yoshida, H., Ohki, M., Ishimoto, N., Mizutani, K., Oshima, M., Muramatsu, M., Wakita, T., Shirouzu, M., Liu, K., Uemura, T., Nomura, N., Iwata, S., Watashi, K., Tame, J. R., Nishizawa, T., Lee, W., and Park, S.:
  "Structural insights into the HBV receptor and bile acid transporter NTCP"
  Nature 606(7916), 1027–1031. (2022).
• 9. Hosaka, T., Nomura, T., Kubo, M., Nakane, T., Luo Fangjia, Sekine, S., Ito, T., Murayama, K., Ihara, K., Ehara, H., Kashiwagi, K., Katsura, K., Akasaka, R., Hisano, T., Tanaka, T., Tanaka, R., Arima, T., Yamashita, A., Sugahara, M., Naito, H., Matsuura, Y., Yoshizawa, S., Tono, K., Owada, S., Nureki, O., Kimura-Someya, T., Iwata, S., Nango, E., and Shirouzu, M.:
  "Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers"
  Proc. Natl. Acad. Sci. U.S.A. 119(9), e2117433119. (2022).
• 10. Kukimoto-Niino, M., Katsura, K., Kaushik, R., Ehara, H., Yokoyama, T., Uchikubo-Kamo, T., Nakagawa, R., Mishima-Tsumagari, C., Yonemochi, M., Ikeda, M., Hanada, K., Zhang, K. Y., and Shirouzu, M.:
  "Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex"
  Sci. Adv. 7(30), eabg3147. (2021).

Recent Research Results

• 

  Sep. 27, 2024
  Structural secrets of antiepileptic drugs uncovered

• 

  Mar. 16, 2023
  A nifty trick to help plants thrive in iron-poor soils

• 

  Jun. 9, 2022
  Imaging how a light-driven chloride pump works

• 

  Nov. 1, 2021
  Mapping the structural features that regulate a signaling protein’s specificity

• 

  Aug. 9, 2019
  How phosphorylation of eIF2 reduces protein synthesis

• 

  Dec. 7, 2018
  Cryo-electron microscopy shows how stabilizing proteins bind to microtubules

Publications

Lab Members

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