Research Summary

Selected Publications

• 1.Okamura E., Ohsawa K., Ban H., Sugiyama Y., Hashimoto J., Kudo K., Yoshida M., Shin-ya K., Ikeda H., Takahashi S., and Doi T.:
  "Characterization of the ketoreductase domain of pikromycin module 2."
  Chem. Sci., 17: 3572-3586 (2026).
• 2.Fujiyama K., Takagi H., Vo N.N.Q., Morita N., Toshihiko Nogawa, Takahashi S.:
  "Structural insights into a bacterial terpene cyclase fused with haloacid dehalogenase-like phosphatase."
  Chem. Sci., 16(34): 15311-1539 (2025).
• 3.Yong Y.F., Liu S., Sakai K., Fujiyama K., Takagi H., Futamura Y., Osada H, Boon Beng Eugene Ong, and Takahashi S.:
  "Biosynthesis of novel reveromycin derivatives by altering the regioselectivity of cytochrome P450revI."
  Chem. Sci., 16(28): 13106-13114 (2025).
• 4.Zheng Y., Sakai K., Takagi H., Watanabe K., Sato-Shiozaki Y., Misumi Y., Kurisu G., Nogawa T., Takita R., Takahashi S.:
  "Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis."
  Nat. Commun., 15(1): 5779 (2024).
• 5.Zheng Y., Morita N., Takagi H., Shiozaki-Sato Y., Jun Ishikawa, Shin-ya K., and Takahashi S.:
  "Alanyl-tRNA synthetase-like enzymes catalyzed aminoacylation in the biosynthesis of nucleoside sulfamate ascamycin."
  ACS Catal., 14: 3533-3542 (2024).
• 6.Sakai K., Futamura Y., Nogawa T., Zhao Y., Koshino H., Osada H., and Takahashi S.:
  "Production of kinanthraquinone D with anti-malarial activity by heterologous gene expression and biotransformation in Streptomyces lividans TK23."
  J. Nat. Prod., 87(4): 855-860 (2024).
• 7.Abdelhakim I.A., Futamura Y., Asami Y., Hanaki H., Kito N., Masuda S., Shibata A., Shirasu K., Osada H., Ishikawa J., and Takahashi S.:
  "Expression of Syo_1.56 SARP Regulator Unveils Unprecedented Elasnin Derivatives with Potent Antibacterial Activity."
  J. Nat. Prod., 87(5): 1459-1470 (2024).
• 8.Hashimoto T., Suenaga H., Amagai K., Hashimoto J., Kozone I., Takahashi S., Kazuo Shin-ya K.:
  "In vitro module editing of NRPS enables production of highly potent Gq-signaling inhibitor FR900359 derived from unculturable plant symbiont."
  Angew. Chem. Int. Ed., 63: e202317805 (2024).
• 9.Fujiyama K., Kato N., Re S., Kinugasa K., Watanabe K., Takita R., Nogawa T., Hino T., Osada H., Sugita Y., Takahashi S., and Nagano S.:
  "Molecular basis for two stereoselective Diels-Alderases that produce decalin skeletons."
  Angew. Chem. Int. Ed., 60: 22401-22410 (2021).
• 10.Kato N., Nogawa T., Takita R., Kinugasa K., Kanai M., Uchiyama M., Osada H., and Takahashi S.:
  "Control of the stereochemical course of [4+2] cycloaddition during trans-decalin formation by Fsa2-family enzymes."
  Angew. Chem. Int. Ed., 57: 9754-9758 (2018).

Recent Research Results

• 

  Apr. 15, 2026
  Catalyzing the production of useful biocompounds

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