RIKEN Center for Integrative Medical Sciences Laboratory for AI-driven Experimental Medicine
Team Director: Jun Seita (M.D., Ph.D.)
Research Summary
The Laboratory for AI-driven Experimental Medicine research and develop systems that combine automated massively parallel experimental and measurement devices with reinforcement learning and world models, enabling AI to autonomously hypothesize, execute, analyze, and learn from scientific experiments.
Main Research Fields
- Complex Systems
Related Research Fields
- Informatics
- Interdisciplinary Science & Engineering
- Biology
- Medicine, Dentistry & Pharmacy
Keywords
- AI
- World Model
- Reinforcement Learning
- Deep Learning
- Autonomous Experiment
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
Yazaki J, Yamanashi T, Nemoto S, Kobayashi A, Han YW, Hasegawa T, Iwase A, Ishikawa M, Konno R, Imami K, Kawashima Y, Seita J.:
"Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry."
Biol Methods Protoc. 29;9(1):bpae039 (2024) - 2.
Ohta T, Hananoe A, Fukushima-Nomura A, Ashizaki K, Sekita A, Seita J, Kawakami E, Sakurada K, Amagai M, Koseki H, Kawasaki H.:
"Best practices for multimodal clinical data management and integration: An atopic dermatitis research case."
Allergol Int. 73(2):255-263. (2024) - 3.
Sekita A, Kawasaki H, Fukushima-Nomura A, Yashiro K, Tanese K, Toshima S, Ashizaki K, Miyai T, Yazaki J, Kobayashi A, Namba S, Naito T, Wang QS, Kawakami E, Seita J, Ohara O, Sakurada K, Okada Y, Amagai M, Koseki H.:
"Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis."
Nat Commun. 2;14(1):6133. (2023) - 4.
Kobayashi M, Wei H, Yamanashi T, Azevedo Portilho N, Cornelius S, Valiente N, Nishida C, Cheng H, Latorre A, Zheng WJ, Kang J, Seita J, Shih DJ, Wu JQ, Yoshimoto M.:
"HSC-independent definitive hematopoiesis persists into adult life."
Cell Rep. 28;42(3):112239. (2023) - 5.
Sato Y, Oguchi A, Fukushima Y, Masuda K, Toriu N, Taniguchi K, Yoshikawa T, Cui X, Kondo M, Hosoi T, Komidori S, Shimizu Y, Fujita H, Jiang L, Kong Y, Yamanashi T, Seita J, Yamamoto T, Toyokuni S, Hamazaki Y, Hattori M, Yoshikai Y, Boor P, Floege J, Kawamoto H, Murakawa Y, Minato N, Yanagita M.:
"CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury."
J Clin Invest. 132(2):e146071. (2022) - 6.
*Travaglini KJ, Nabhan AN, Penland L, Sinha R, Gillich A, Sit RV, Chang S, Conley SD, Mori Y, Seita J, Berry GJ, Shrager JB, Metzger RJ, Kuo CS, Neff N, Weissman IL, Quake SQ, Krasnow MA.:
"A molecular cell atlas of the human lung from single cell RNA sequencing"
Nature 587(7835):619 (2020) - 7.
Yazaki J, Kawashima Y, Ogawa T, Kobayashi A, Okoshi M, Watanabe T, Yoshida S, Kii I, Egami S, Amagai M, Hosoya T, Shiroguchi K, Ohara O.:
"HaloTag-based conjugation of proteins to barcoding-oligonucleotides"
Nucleic Acids Res. 48(2):e8 (2020) - 8.
Kawashima Y, Watanabe E, Umeyama T, Nakajima D, Hattori M, Honda K, Ohara O.:
"Optimization of Data-Independent Acquisition Mass Spectrometry for Deep and Highly Sensitive Proteomic Analysis"
Int J Mol Sci. 20(23) 5932 (2019) - 9.
Kawashima Y, Miyata J, Watanabe T, Shioya J, Arita M, Ohara O.:
"Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent"
J Proteome Res. 18(1), 301-308 (2019) - 10.
Rosental B, Kowarsky M, Seita J, Corey DM, Ishizuka KJ, Palmeri KJ, Chen SY, Sinha R, Okamoto J, Mantalas G, Manni L, Raveh T, Clarke DN, Tsai JM, Newman AM, Neff NF, Nolan GP, Quake SR, Weissman IL, Voskoboynik A.:
"Complex mammalian-like haematopoietic system found in a colonial chordate"
Nature. 564(7736) 425 (2018)
Recent Research Results
Related Links
Lab Members
Principal investigator
- Jun Seita
- Team Director
Core members
- Dorothy DeMore Ellis
- Postdoctoral Researcher
- Tomoko Hasegawa
- Senior Technical Staff
- Atsuo Kobayashi
- Technical Staff I
- Fumie Yokoyama
- Technical Staff I
- Reiko Kuwahara
- Technical Staff I
- Takashi Yamanashi
- Student Trainee
Careers
| Position | Deadline |
|---|---|
| Seeking a Senior Research Scientist, Research Scientist or Postdoctoral Researcher (25-1550) | Open until filled |
Contact Information
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Email: ims-web@riken.jp
