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RIKEN Center for Integrative Medical Sciences Laboratory for AI-driven Experimental Medicine

Team Director: Jun Seita (M.D., Ph.D.)

Research Summary

Jun Seita

The Laboratory for AI-driven Experimental Medicine research and develop systems that combine automated massively parallel experimental and measurement devices with reinforcement learning and world models, enabling AI to autonomously hypothesize, execute, analyze, and learn from scientific experiments.

Main Research Fields

  • Complex Systems

Related Research Fields

  • Informatics
  • Interdisciplinary Science & Engineering
  • Biology
  • Medicine, Dentistry & Pharmacy

Keywords

  • AI
  • World Model
  • Reinforcement Learning
  • Deep Learning
  • Autonomous Experiment

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. Yazaki J, Yamanashi T, Nemoto S, Kobayashi A, Han YW, Hasegawa T, Iwase A, Ishikawa M, Konno R, Imami K, Kawashima Y, Seita J.:
    "Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry."
    Biol Methods Protoc. 29;9(1):bpae039 (2024)
  • 2. Ohta T, Hananoe A, Fukushima-Nomura A, Ashizaki K, Sekita A, Seita J, Kawakami E, Sakurada K, Amagai M, Koseki H, Kawasaki H.:
    "Best practices for multimodal clinical data management and integration: An atopic dermatitis research case."
    Allergol Int. 73(2):255-263. (2024)
  • 3. Sekita A, Kawasaki H, Fukushima-Nomura A, Yashiro K, Tanese K, Toshima S, Ashizaki K, Miyai T, Yazaki J, Kobayashi A, Namba S, Naito T, Wang QS, Kawakami E, Seita J, Ohara O, Sakurada K, Okada Y, Amagai M, Koseki H.:
    "Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis."
    Nat Commun. 2;14(1):6133. (2023)
  • 4. Kobayashi M, Wei H, Yamanashi T, Azevedo Portilho N, Cornelius S, Valiente N, Nishida C, Cheng H, Latorre A, Zheng WJ, Kang J, Seita J, Shih DJ, Wu JQ, Yoshimoto M.:
    "HSC-independent definitive hematopoiesis persists into adult life."
    Cell Rep. 28;42(3):112239. (2023)
  • 5. Sato Y, Oguchi A, Fukushima Y, Masuda K, Toriu N, Taniguchi K, Yoshikawa T, Cui X, Kondo M, Hosoi T, Komidori S, Shimizu Y, Fujita H, Jiang L, Kong Y, Yamanashi T, Seita J, Yamamoto T, Toyokuni S, Hamazaki Y, Hattori M, Yoshikai Y, Boor P, Floege J, Kawamoto H, Murakawa Y, Minato N, Yanagita M.:
    "CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury."
    J Clin Invest. 132(2):e146071. (2022)
  • 6. *Travaglini KJ, Nabhan AN, Penland L, Sinha R, Gillich A, Sit RV, Chang S, Conley SD, Mori Y, Seita J, Berry GJ, Shrager JB, Metzger RJ, Kuo CS, Neff N, Weissman IL, Quake SQ, Krasnow MA.:
    "A molecular cell atlas of the human lung from single cell RNA sequencing"
    Nature 587(7835):619 (2020)
  • 7. Yazaki J, Kawashima Y, Ogawa T, Kobayashi A, Okoshi M, Watanabe T, Yoshida S, Kii I, Egami S, Amagai M, Hosoya T, Shiroguchi K, Ohara O.:
    "HaloTag-based conjugation of proteins to barcoding-oligonucleotides"
    Nucleic Acids Res. 48(2):e8 (2020)
  • 8. Kawashima Y, Watanabe E, Umeyama T, Nakajima D, Hattori M, Honda K, Ohara O.:
    "Optimization of Data-Independent Acquisition Mass Spectrometry for Deep and Highly Sensitive Proteomic Analysis"
    Int J Mol Sci. 20(23) 5932 (2019)
  • 9. Kawashima Y, Miyata J, Watanabe T, Shioya J, Arita M, Ohara O.:
    "Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent"
    J Proteome Res. 18(1), 301-308 (2019)
  • 10. Rosental B, Kowarsky M, Seita J, Corey DM, Ishizuka KJ, Palmeri KJ, Chen SY, Sinha R, Okamoto J, Mantalas G, Manni L, Raveh T, Clarke DN, Tsai JM, Newman AM, Neff NF, Nolan GP, Quake SR, Weissman IL, Voskoboynik A.:
    "Complex mammalian-like haematopoietic system found in a colonial chordate"
    Nature. 564(7736) 425 (2018)

Recent Research Results

Related Links

Lab Members

Principal investigator

Jun Seita
Team Director

Core members

Dorothy DeMore Ellis
Postdoctoral Researcher
Tomoko Hasegawa
Senior Technical Staff
Atsuo Kobayashi
Technical Staff I
Fumie Yokoyama
Technical Staff I
Reiko Kuwahara
Technical Staff I
Takashi Yamanashi
Student Trainee

Careers

Position Deadline
Seeking a Senior Research Scientist, Research Scientist or Postdoctoral Researcher (25-1550) Open until filled

Contact Information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Email: ims-web@riken.jp

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