RIKEN Center for Advanced Photonics Optical Life Metrology Research Team
Team Director: Takuro Ideguchi (Dr. rer. nat.)
Research Summary
Microscopic observation of biological specimens such as cells and tissues is a fundamental technique in life sciences. We develop advanced laser-based, label-free quantitative imaging methods that enable visualization of molecular and structural information without staining. Our research includes vibrational microscopy for quantitative chemical analysis and high-sensitivity scattering microscopy for spatiotemporal characterization of microstructures and nanoparticles. Using these original technologies, we also investigate biophysical phenomena such as intracellular thermal dynamics. Through these efforts, we aim to pioneer Optical Life Metrology—an interdisciplinary field bridging photonics and the life sciences.
Main Research Fields
- Interdisciplinary Science & Engineering
Related Research Fields
- Engineering
- Mathematical & Physical Sciences
- Biological Sciences
- Optical engineering and photon science-related
- Biophysics, chemical physics and soft matter physics-related
- Biophysics-related
Keywords
- Laser
- Spectroscopy
- Microscopy
- Biophotonics
- Bioimaging
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
*Horie, K., Toda, K., Nakamura, T., and Ideguchi, T.:
"Bidirectional quantitative scattering microscopy,"
Nature Communications 16, 9712 (2025). - 2.
*Toda, K., and Ideguchi, T.:
"Ludwig-Soret microscopy with the vibrational photothermal effect,"
PNAS 122, e2510703122 (2025). - 3.
*Tamamitsu, M., Toda, K., Fukushima, M., Badarla, V. R., Shimada, H., Ota, S., Konishi, K., and Ideguchi, T.:
"Mid-infrared wide-field nanoscopy,"
Nature Photonics 18, 738–743 (2024). - 4.
*Ishigane, G., Toda, K., Tamamitsu, M., Shimada, H., Badarla, V. R., Ideguchi, T.:
"Label-free mid-infrared photothermal live-cell imaging beyond video rate"
Light: Science & Applications 12, 174 (2023). - 5.
*Hashimoto, K., Nakamura, T., Kageyama, T., Badarla, V. R., Shimada, H., Horisaki, R., and Ideguchi, T.:
"Upconversion time-stretch infrared spectroscopy,"
Light: Science & Applications 12, 48 (2023). - 6.
*Hashimoto, K., Badarla, V. R., Kawai, A., and Ideguchi, T.:
"Complementary Vibrational Spectroscopy,"
Nature Communications 10, 4411 (2019). - 7.
*Hiramatsu, K., Ideguchi, T., Yonamine, Y., Lee, S. W., Luo, Y., Hashimoto, K., Ito, T., Hase, M., Park, J. W., Kasai, Y., Sakuma, S., Hayakawa, T., Arai, F., Hoshino, Y., and Goda, K.:
"High-throughput label-free molecular fingerprinting flow cytometry "
Science Advances 5, aau0241 (2019) - 8.
*Hashimoto, K., and Ideguchi, T.:
"Phase-controlled Fourier-transform spectroscopy"
Nature Communications 9, 4448 (2018) - 9.
*Ideguchi, T., Poisson, A., Guelachvili, G., Picqué, N., and Hänsch, T. W.:
"Adaptive real-time dual-comb spectroscopy"
Nature Communications 5, 3375 (2014) - 10.
*Ideguchi, T., Holzner, S., Bernhardt, B., Guelachvili, G., Picqué, N., and Hänsch, T. W.:
"Coherent Raman spectro-imaging with laser frequency combs"
Nature 502, 355-358 (2013)
Lab Members
Principal investigator
- Takuro Ideguchi
- Team Director
Contact Information
Email: takuro.ideguchi@riken.jp